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Serotonin – Full Definition

Serotonin - Full Definition

Serotonin Full Definition

Definition of Serotonin

Define Serotonin

Serotonin – se·​ro·​to·​nin | \ ˌsir-ə-ˈtō-nənˌser- \ – noun
: a phenolic amine neurotransmitter C10H12N2O that is a powerful vasoconstrictor and is found especially in the brain, blood serum, and gastric mucous membrane of mammals.
: a biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

Examples of serotonin in a Sentence
Recent Examples on the Web –
Most antidepressants like Prozac and Effexor modify brain signalling pathways used by the chemicals dopamine and serotonin: two major players in mood regulation. — Popular Science, “Two radically new drugs bring hope for people with depression. But psychiatrists are skeptical.,” 31 Dec. 2019

The primary neuroreceptor that mediates psychedelics’ psychoactivity, the serotonin 2A receptor, is also known to play a key role in regulating immune function. — Shlomi Raz, STAT, “Transforming psychedelics into mainstream medicines,” 7 Jan. 2020

First Known Use of serotonin
1948, in the meaning defined above

History and Etymology for serotonin
sero- + ton(ic) entry 2 or tone entry 1 + -in entry 1, probably after angiotonin, earlier name for angiotensin — more at angiotensin
Note: Term introduced by Maurice M. Rapport, Arda Alden Green and Irvine H. Page in “Crystalline serotonin,” Science, vol. 108, Issue 2804 (September 24, 1948), pp. 329-330: “The general behavior of the crystalline substance is suggestive of its homogeneity. We would like provisionally to name it serotonin, which indicates that its source is serum and its activity is one of causing constriction.”


1H-Indol-5-ol, 3-(2-aminoethyl)- | 3-(2-Aminoethyl)-1H-indol-5-ol | 5 Hydroxytryptamine | 5-HT | 5-Hydroxytryptamine | Enteramine | Hippophaine | Hydroxytryptamine

Source – Merriam-Webster

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