retinoblastoma – /ˌrɛtɪnəʊblaˈstəʊmə/ – noun
: a rare malignant tumour of the retina, affecting young children.
: a malignant tumor of the retina that develops during childhood, is derived from retinal germ cells, and is associated with a chromosomal abnormality
: a malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
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